Prospective insight into the role of benzyl propylene glycoside as a modulator of the cGAS-STING signaling pathway in the management of nonalcoholic fatty pancreas animal model

BACKGROUND: Nonalcoholic fatty pancreatitis (NAFP) is one of the metabolic syndrome manifestations that need further studies to determine its molecular determinants and find effective medications. We aimed to investigate the potential effect of benzyl propylene glycoside on NAFP management via targeting the pancreatic cGAS-STING pathway-related genes (DDX58, NFκB1 & CHUK) and their upstream regulator miRNA (miR-1976) that were retrieved from bioinformatics analysis. METHODS: The rats were fed either normal chow or a high-fat high-sucrose diet (HFHS), as a nutritional model for NAFP. After 8 weeks, the HFHS-fed rats were subdivided randomly into 4 groups; untreated HFHS group (NAFP model group) and three treated groups which received 3 doses of benzyl propylene glycoside (10, 20, and 30 mg/kg) daily for 4 weeks, parallel with HFHS feeding. RESULTS: The molecular analysis revealed that benzyl propylene glycoside could modulate the expression of the pancreatic cGAS-STING pathway-related through the downregulation of the expression of DDX58, NFκB1, and CHUK mRNAs and upregulation of miR-1976 expression. Moreover, the applied treatment reversed insulin resistance, inflammation, and fibrosis observed in the untreated NAFP group, as evidenced by improved lipid panel, decreased body weight and the serum level of lipase and amylase, reduced protein levels of NFκB1 and caspase-3 with a significant reduction in area % of collagen fibers in the pancreatic sections of treated animals. CONCLUSION: benzyl propylene glycoside showed a potential ability to attenuate NAFP development, inhibit pancreatic inflammation and fibrosis and reduce the pathological and metabolic disturbances monitored in the applied NAFP animal model. The detected effect was correlated with modulation of the expression of pancreatic (DDX58, NFκB1, and CHUK mRNAs and miR-1976) panel.

Non-insulin diabetic patients' knowledge and their compliance

The present study aimed at investigating how the Egyptian individuals with type II diabetes monitor their disease status by comparing their current state with their standard of well being. A sample of convenience of 100 NIDDM was selected. Two tools were used for data collection; background data sheet and questionnaire sheet. Descriptive statistics T-test, ANOVA test and X2-analysis were used. The results indicated that there was a positive relationship between patient's self-regulation and patient's characteristics as sex, level of education and occupation, respectively. Also, very high percentage of patient's sample [65%] is over weight. A highly statistical significant difference was found regarding action taken when the patient got health problem and type of patient's occupation. The study also indicated that minority of the sample practiced exercise

Meeting the challenges of coma consequences: development of an instructional nursing intervention plan for comatose patients

The purpose of this study was to detect the direct cause which lead to complications in comatose patients as well as to construct an instructional nursing intervention plan in order to prevent complications following coma. The results indicated that the highest effect which is most leading to coma complications is the long period of hospital stay [multiple r = 0.3829] followed by old age [multiple r = 0.0906, X = 57.9 + 17.3] and nurses performance [multiple r = 0.0640, 81% were scored as unsatisfactory, 14% need more practice and 5% satisfactory]. The study concluded that there is a positive statistical significant correlation between complication and hospital stay and patients' age. While nurses performance was negatively correlated with the prevalence of complications and low nurse-patient ratio